Introduction: Hilar hyalinosis (HH) of glomeruli has been thought for a long time to be a precursor or a variant of focal glomerulosclerosis (FGS). In view of its implications on treatment and prognosis of nephrotic syndrome, a retrospective study of hilar hyalinosis in children with the idiopathic nephrotic syndrome (INS), but without any other histologic evidence of FGS, was performed to determine the clinic-pathologic significance of this lesion.
Methods: A total of 92 Children with INS who had kidney biopsies for frequent relapses, steroid dependency or resistance were included. Eight of them had a biopsy-proven diagnosis of either minimal change disease or mild IgM nephropathy with HH in 6-25% of glomeruli were compared to control group consisting of 84 children with either minimal change disease (n=57) or IgM nephropathy (n=27) but without HH.
Results: Clinically HH patients presented with NS and followed a steroid-dependent relapsing course prior to biopsy. Around 75% of the HH patients received at least one course of cytotoxic therapy after biopsy. At last visit, 6 patients were in remission, 2 were protein-free but on medication. None had hypertension or renal insufficiency. Apart from having a shorter interval between presentation and biopsy (P<0.001) and a lower remission rate (P<0.05), control patients followed a similar course.Pathologically HH patients showed less mesangial change (P<0.001) than the controls but similar mean glomerular size and tubuloinerstitial damage.
Keywords:
Published on: Aug 3, 2015 Pages: 8-11
Full Text PDF
Full Text HTML
DOI: 10.17352/2455-5495.000003
CrossMark
Publons
Harvard Library HOLLIS
Search IT
Semantic Scholar
Get Citation
Base Search
Scilit
OAI-PMH
ResearchGate
Academic Microsoft
GrowKudos
Universite de Paris
UW Libraries
SJSU King Library
SJSU King Library
NUS Library
McGill
DET KGL BIBLiOTEK
JCU Discovery
Universidad De Lima
WorldCat
VU on WorldCat
PTZ: We're glad you're here. Please click "create a new query" if you are a new visitor to our website and need further information from us.
If you are already a member of our network and need to keep track of any developments regarding a question you have already submitted, click "take me to my Query."