Open Access Research Article Article ID: AOR-3-152

    Evaluation of the efficacy of the utilization of the imipramine for patients with allergic rhinitis

    Diaa El Din El Hennawi, Mohamed Rifaat Ahmed*, Yasser T Madian, Mohammed T El-Tabbakh and Ibrahim Hassan Ibrahim

    Background: allergic rhinitis is an infl ammatory process of the upper respiratory tract with a continuous symptom that last for hour or more with symptom affect patient’s work and quality of life. 

    Methodology: a randomized controlled trial in which we enrolled 284 patients with allergic rhinitis for periods longer than 4 days/week and for more than 4 consecutive weeks divided into two groups. Group A (n=142) received Imipramine 75 mg/day for 90 days .Group B (n=142), the control group, received desloratadine 5 mg / day for 90 days.

    Results: The mean visual analogue score nasal symptoms intensity (sneezing, Nasal obstruction, watery rhinorrhea and itchy nose) showed a statistically signifi cantly improvement in group A (treated with Imipramine) compared with group B (treated with desloratadine) after the same treatment period.

    Conclusion: Imipramine could be used in treatment patients with allergic rhinitis as it is effective as an antihistaminic besides its main action in reliving psychosocial stresses.


    Published on: Jul 26, 2017 Pages: 79-82

    Full Text PDF Full Text HTML DOI: 10.17352/2455-1759.000052
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