Lipid nanoparticulate drug delivery system for the treatment of hepatic fibrosis

Swarupananda Mukherjee*, Ayon Dutta and Dipanjana Ash

Background: Irreversible hepatic fibrosis, an excessive production and accumulation of extra cellular matrix by hepatic stellate cells in the liver, becomes a remarkable economic burden in global health care system.Low therapeutic efficacy and undesirable systemic effect of conventional therapies limit their clinical applications to targethepatic stellate cells.

Method: Surface engineered lipid nano-particle becomes a potential candidate to deliver anti-fibrotic nutrients or Small interfering RNA (siRNA) of fibrogenic genes for treating hepatic disorders. 

Conclusion: This mini review focuses on different strategies of surface engineered organic lipid nanoparticles for the treatment of hepatic fibrosis by targeting specific and un-specific Hepatic Stellate Cells (HSCs).

Keywords:

Published on: Jan 28, 2021 Pages: 1-3

Full Text PDF Full Text HTML DOI: 10.17352/ahr.000028
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