Electrophysiological Profiling of Depression in the Elderly

Jenny L Patterson, J. Bruce Barber, Daniel W. O Connor and Samia R Toukhsati

Frontostriatal system functioning has been  proposed to underpin  performance on executive functioning tasks; these structures are abnormally activated in adults with depression. In this study, the P200 and P300 event-related potentials (ERPs) were elicited during a classic two-tone auditory oddball task to compare the electrophysiological profiles of elderly people (N = 54; Mean age = 85.46 ± 6.21) diagnosed with clinical depression ( n  = 17), subthreshold depression ( n  = 25) or no depression ( n  = 12). The P200 results revealed higher amplitude and significantly longer latencies in depressed groups relative to non-depressed  participants. Higher P300 amplitude, but shorter latencies, were observed  in depressed relative to non-depressed participants.  Findings  are  discussed  in  terms  of cognitive information processing models of ERPs and the potential for non-cognitive factors to impact on the resulting electrophysiological profile.

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Published on: Jul 23, 2016 Pages: 31-36

Full Text PDF Full Text HTML DOI: 10.17352/2455-5460.000012
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