The current definition of cancer is the creation of atypical cells capable to rapidly grow beyond the normal boundaries and spread to distant organs. To do so tumour cells have to acquire to the ability to proliferate continuously and avoid apoptosis. An important role in this process is played by growth factors and their receptors. Amongst many, one of the most important interaction is between the Epidermal growth factor (EGF) and its receptor (EGFR) which are frequently mutated or upregulated in human cancers particularly in non-small cell carcinoma of the lung (NSCLC). The biding leads to protein activation, cell proliferation and decreased apoptosis. However, in this subset of tumours, the blockage of this interaction by EGFR-targeting drugs has shown an overall outcome improvement leading to the era of target therapy. The result is that patients are now routinely screened for a series of actionable mutations to be given the best possible therapy available for their specific type of tumour limiting the side effect of broad-spectrum chemotherapy. This paper will review the biology of EGFR receptor, the type and role of its mutation and the clinical implication for patients with NSCLC harbouring these mutations.
Keywords:
Published on: May 4, 2020 Pages: 48-53
Full Text PDF
Full Text HTML
DOI: 10.17352/acp.000015
CrossMark
Publons
Harvard Library HOLLIS
Search IT
Semantic Scholar
Get Citation
Base Search
Scilit
OAI-PMH
ResearchGate
Academic Microsoft
GrowKudos
Universite de Paris
UW Libraries
SJSU King Library
SJSU King Library
NUS Library
McGill
DET KGL BIBLiOTEK
JCU Discovery
Universidad De Lima
WorldCat
VU on WorldCat
PTZ: We're glad you're here. Please click "create a new query" if you are a new visitor to our website and need further information from us.
If you are already a member of our network and need to keep track of any developments regarding a question you have already submitted, click "take me to my Query."