Open Access Letter to Editor Article ID: ABMR-6-108

    Acute Panmyelosis with Myelofibrosis: The Serpentine Road to Diagnosis

    Celia Suriu, Andrei Braester* and Masad Barhoum

    Acute Panmyelosis with Myelofibrosis (APMF) is an extremely rare disease. Lack of familiarity with this rare subtype of acute leukemia hinders the diagnosis [1]. It is characterized by an acute, rapidly progressive, fatal clinical course, peripheral blood cytopenias with minimum 20% blast and no detectable splenomegaly. APMF corresponds to less than 1% of the cases of Acute Myeloid Leukemia (AML) [2]. Histologically, APMF is characterized by a heavily fibrotic marrow, an increased number of immature hematopoietic elements (panmyelosis), and dysplastic population of megakaryocytes. The condition should be differentiated from other hematological neoplasms that present with fibrosis such as acute megakaryoblastic leukemia and myelodysplsia (MDS) with myelofibrosis. Dacrocytes are not present.


    Published on: May 13, 2021 Pages: 7-8

    Full Text PDF Full Text HTML DOI: 10.17352/abmr.000008
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