Citicoline in Vascular Cognitive Impairment: Some Latest Evidences

Pietro Gareri* and Alberto Castagna

CDP-choline (cytidine-5′-diphosphate choline), also called citicoline, is one of the most frequently pre scribed drugs for cognitive impairment in several European countries and worldwide [1–3].

In clinical practice, a number of different studies have shown that citicoline is effective in Parkinson’s disease, glaucoma, amblyopia, head trauma and cognitive impairment (CI) of diverse etiology, such as in CI following cerebrovascular disease [1-4].

Citicoline is able to inhibit apoptosis associated with cerebral isch emia and several models of neurodegeneration [1–3]. It can also potentiate neuroplasticity and is a natural precursor of phosphatidylcholine, one of the most important structural phospholipids in the neuronal membranes.Furthermore, since it is formed by choline, it works for biosynthesis of acetylcholine [1–3], CDP-choline increases cerebral metabolism, noradrenaline, and dopamine levels in the cen tral nervous system (CNS) [1,4].

Keywords:

Published on: Jul 17, 2017 Pages: 18-19

Full Text PDF Full Text HTML DOI: 10.17352/aadc.000004
CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat