Open Access Review Article Article ID: AADC-1-102

    Can Exposure to Volatile Anesthetics Be a Tipping Point for AD Susceptible Populations?

    Ingrid R Niesman*

    The relationship between surgery induced Postoperative Cognitive Dysfunction (POCD) and the development of Alzheimer’s disease (AD) later has been a debatable question. Volatile anesthetics represent a potential environmental factor that can change the CNS both acutely and long-term. By interacting with membrane cholesterol to alter signaling in neurons or alter the normally quiescent microglial phenotype, volatile anesthetics are implicated in the development of POCD. The tipping point for triggering AD cyclic pathology may rest with individual AD genetic risk factors combined with the known molecular consequences of anesthetic exposure. This review covers genome wide association studies (GWAS) identified AD risk factors, actions of volatile anesthetics in the development of AD phenotypes and presents some newly discovered pre or post-anesthetic POCD attenuating therapies.

    Keywords: Isofl urane; GWAS; Neuroinfl ammation; Berberine; Minocycline; Deferoxamine; POCD

    Published on: Feb 22, 2017 Pages: 7-12

    Full Text PDF Full Text HTML DOI: 10.17352/aadc.000002
    CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat


    Global Views

    Case Reports

    Peertechz Tweets

    Pinterest on AADC

    Help ? Google Reviews 11