Autoimmune hepatitis associated Hepatitis C virus infection treated with fi rst generation direct-acting antivirals

Juan Diego Castro Limo, Tomas Artaza Varasa*, Maria Recuero Pradillo, Marta Romero-Gutierrez, Ana Zaida Gomez Moreno, Juan Jose Sanchez Ruano, Carlos San Roman Gutierrez, Pablo Munoz Gomez and Rafael Gomez Rodríguez

The hepatitis C virus (HCV) infection has been associated with autoimmune diseases, probably due to the interaction between HCV E2 envelope protein and CD-81 receptor of B lymphocyte and thus, can infl uence the pathogenesis of autoimmune liver diseases [1,2]. Therefore, it seems reasonable to consider the benefi cial effect of direct-acting antivirals (DAAs) for HCV in patients with chronic HCV infection and autoimmune hepatitis (HAI), although evidence is scarce. We report the case of an HCV-infected patient who developed an HAI triggered by interferon and since then has been treated with DAAs improving liver function and maintaining sustained virologic response (SVR), without immunosuppressive treatment nowadays.

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Published on: Oct 4, 2019 Pages: 6-8

Full Text PDF Full Text HTML DOI: 10.17352/aaa.000006
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