Meriem N Mrabent1, Noria Harir1, Feriel Sellam1*, Soumia Zeggai1, Abdenacer Tou2, Mustapha Diaf1, Rachida Salah1 and Soraya Moulesshoul1
1Laboratory of Molecular Microbiology, Proteomics and Health, Departement of Biology, Djillali Liabes University of Sidi bel Abbes, Algeria
2Department of Pathology; Hospital of Sidi bel Abbes, Algeria
Received: 12 September, 2015; Accepted: 26 October, 2015; Published: 28 October, 2015
Feriel Sellam, PhD, Department of Biology, Djillali Liabes University of Sidi bel Abbes, (Ex ITMA), Algeria candidate in Cellular Biology and Pathology, E-mail:
Mrabent MN, Harir N, Sellam F, Zeggai S, Tou A, et al. (2015) HER2 Status in Male Breast Carcinoma: a Single North African Institution Experience of 10 Cases and Review of the Literature. J Surg Surgical Res 1(3): 049-052. 10.17352/2455-2968.000013
© 2015 Mrabent MN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Breast cancer; Man; Overexpression; ER; PR; HER2
Background: To investigate clinic-pathological characteristics, hormonal receptors and HER2 receptor of male breast cancer.
Materials and methods: Retrospective study of 10 cases between 2010 and 2013. The studied parameters were: tumor size, histological type, histological grade, lymph node status, hormonal status and overexpression of HER2.
Results: The average age of our patients was 60.2 years, in 70% of cases; the histological size that was found was T4; and infiltrating ductal carcinoma was diagnosed in all cases. The grades classification was as follow: grade 2 (30%) and grade 3 (70%). 70% of cases had lymph node metastasis. Estrogen and progesterone receptors (ER,PR) were positive in 60% of tumors. Overexpression of HER2 was positive (Score3) in one case. Luminal B was the most common subtype in our study.
Conclusion: Male breast cancer is a rare disease with a poor prognosis despite the recent increase in incidence in recent years. The diagnosis is often delayed and injuries are treated in advanced stages.
Breast cancer in men is a rare disease and makes up approximately 1% of all cases of breast cancer [1,2]. The rarity of this entity precludes prospective randomized trials. During 2014 in the USA, about 2,360 new cases of invasive breast cancer were diagnosed in men and about 430 men died from the disease . The etiology of male breast cancer is unclear, but hormone levels and testicular abnormalities play a role in the development of this disease [4,5]. Other recognized risk factors include radiation exposure, family history of breast cancer, Klinefelter syndrome, and different benign breast conditions [4,5].
Previous reports have suggested that cancers of the male breast are more likely than female breast cancers to have a ductal histology and are significantly more likely to express hormone receptors [6,7]. Early reports suggested equivalent or even higher rates of human epidermal growth factor receptor 2 (HER2) overexpression in male breast cancer versus female breast cancer [8,9]. Overexpression of the oncoprotein HER2 observed in 10-15% of patients could justify prescribing trastuzumab. In the context of the considerable progress achieved in the recent years concerning female’s breast cancer management, it seems important to review the acquired data and to exploit these advances in order to improve male breast cancer care . In this study we will explore the following pathological parameters: histological type, tumor size, histological grade, lymph node status, hormonal and HER2 status of male breast cancer from western Algeria and compared them with different literatures data.
Material and Method
This cross sectional study was done at the department of pathology at Sidi Bel Abbes University Hospital in Western Algeria from 2010 to 2013. The Male patients with breast cancer were selected for the study. The cases were stained with hematoxyline and eosin (H&E) for routine histological examination. An absolute confidentiality of the patients’ vital information was maintained for ethical purposes and an ethical approval was obtained from institutions in which the study was carried out. We used immunohistochemistry to evaluate the expression of HER2, ER, and PR receptor.
Immunohistochemical expression of HER2 was evaluated according to the published scoring guidelines of the ‘HercepTest’ (Dako, Carpinteria, CA). Herceptest of score 3+ was considered as positive. Four subtypes were defined: 1) Luminal A; oestrogen receptor (ER) + and/or progesterone receptor (PR) +, HER2 -, grade 1 or grade 2 tumours, 2) Luminal B; ER + and/or PR + and HER2 + tumours or ER+ and /or PR+ and HER2- grade 3 tumours, 3) HER2+; ER -, PR- and HER2 + tumours, 4) Triple negative; ER-, PR-,HER2- tumours.
Graph and circles were done using the SPSS Inc. software (Version20).
10 patients with breast cancer were included; and all of them were men. Median age was about 60.2 years (range, 42-80); The most affected age groups were 52-61 years (40%) followed by 62 -71 age group (30%) (Figure 1).
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