Elizabeth Dacey1, O John Ma2 and Peter Stenzel1*
1Department of Pathology and Laboratory Medicine, Oregon Health and Science University, Portland Oregon, USA
2Department of Emergency Medicine, Oregon Health and Science University, Portland Oregon, USA
Received: 24 June, 2016; Accepted: 24 June, 2016; Published: 25 August, 2016
Peter Stenzel, MD, PhD, Department of Pathology, Oregon Health and Science University, Portland, Oregon, United States of America; 3181 SW Sam Jackson, Portland, Oregon, USA, Tel: 1-503-494-2310; Fax: 1-503-494-2025; E-mail:
Dacey E, John Ma O, Stenzel P (2016) Papillary Laryngeal Carcinoma Presenting as Laryngeal Obstruction and Fatal Intractable Hypoxemia. Arch Otolaryngol Rhinol 2(1): 051-052. DOI: 10.17352/2455-1759.000024
© 2015 Dacey E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Unexpected acute laryngeal obstruction is most often caused by foreign bodies or edema and rarely by cysts, infection, or neoplasia. Neoplastic cases include soft tissue tumors and benign epithelial tumors. We report a case of fatal, unexpected, sudden asphyxia due to laryngeal obstruction by a papillary squamous cell carcinoma, a unique presentation of laryngeal squamous cell carcinoma and in this case an unusual histologic pattern. A 61-year-old man experienced respiratory distress while at work. Laryngeal obstruction was discovered in the emergency department. Cricothyrotomy was performed, but his blood oxygen saturation levels failed to improve and he died after a prolonged resuscitation. Autopsy revealed a papillary squamous cell carcinoma on the inferior aspect of the right vocal fold. We suggest that this unusual presentation of laryngeal carcinoma may be due to the unusual histologic features of the tumor.
A 61 year-old man was emergently transported to the emergency department with extreme respiratory distress and a decreased level of alertness. His oxygen saturations were in the 60s and only improved to the 80s with CPAP. He had been complaining of worsening shortness of breath all day at work and was found tripoding when EMS personnel arrived. Upon admission to the emergency department, the patient was unable to provide any history due his altered mental status. Additionally, there was no medical history on file for this patient.
The patient’s initial vital signs showed a temperature of 36.9°C, pulse 148, respirations 33, and oxygen saturation of 92% on 100% oxygen. On physical exam, the patient was in extreme respiratory distress and unable to speak. His neck was supple with no jugular vein distention and his trachea was midline. There were diminished breath sounds, inspiratory and expiratory wheezes, and poor aeration bilaterally. He was tachycardic with palpable pulses and his skin was notable for peripheral mottling throughout. He had a Glascow Coma Scale score of 9. An electrocardiogram did not reveal any ST segment changes. Because there was concern that the patient could not protect his airway and his oxygen saturations were dropping despite supplemental oxygen, the decision was made to secure his airway and place him on mechanical ventilation. Two endotracheal intubation attempts were made. Both attempts were unsuccessful due to the presence of a sizable, undifferentiated laryngeal mass and swollen larynx. No foreign body was present. A cricothyrotomy was then performed. Despite these interventions, the patient’s saturations continued to plummet, he went into cardiac arrest, and a prolonged resuscitation attempt was ultimately unsuccessful. Epinephrine was not utilized initially because the patient had no history of laryngeal cancer and the obstructing tumor and associated edema were not evident until direct laryngoscopy during the intubation attempt.
On autopsy, external examination was notable only for mild clubbing of the digits. The internal exam revealed a right papillary mass measuring 1.2 x 1.5 cm on the inferior aspect of the right vocal fold (Figure 1). No foreign body was present. The lungs were severely emphysematous and weighed 1458 grams (left) and 1513 grams (right); normal weight for each lung is approximately 500 grams. Moderate to severe atherosclerosis of the aorta and left anterior descending coronary artery as well as left ventricular scarring were present. In addition, right ventricular hypertrophy and pulmonary artery atherosclerosis were found. Microscopy of the laryngeal mass showed a well-differentiated squamous cell carcinoma with finger-like projections containing fibro vascular cores (Figure 1). The lesion also exhibited hyperkeratosis, reactive inflammation, necrosis, and invasion into skeletal muscle. These characteristics led to a diagnosis of invasive papillary squamous cell carcinoma of the larynx. A complete autopsy revealed no other site of malignancy.
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