Hari S Sharma1,3,4, Dafin F Muresanu2,3, José Vicente Lafuente4, Ranjana Patnaik5, Z Ryan Tian6, Asya Ozkizilcik7, Herbert Mössler3,8 and Aruna Sharma1,3,4*
1Dept. of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, SE-75185 Uppsala, Sweden
2Dept. Clinical Neurosciences, University of Medicine & Pharmacy, Cluj-Napoca, Romania
3‘‘RoNeuro’’ Institute for Neurological Research and Diagnostic, 37 Mircea Eliade Street, 400364, Cluj-Napoca, Romania
4University of Basque Country, Dept of Neurosciences, Bilbao, Spain
5School of Biomedical Engineering, Dept. of Biomaterials, Indian Institute of technology, Banaras Hindu University, Varanasi, India
6Dept. Chemistry & Biochemistry, University of Arkansas, Fayetteville, AR, USA
7Dept. Biomedical Engineering, University of Arkansas, Fayetteville, AR, USA
8Ever NeuroPharma, Oberburgau, Austria
Received: 02 January, 2016; Accepted: 02 January, 2016; Published: 07 January, 2016
*Corresponding author:
Aruna Sharma, Dept. of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, SE-75185 Uppsala, Sweden, E-mail: @: @
Sharma HS, Muresanu DF, Lafuente JV, Patnaik R, Tian ZR, et al. (2016) Need to Explore Nanodelivery of Stem Cells with Multimodal Drug like Cerebrolysin for Effective Strategies for Enhanced Neuroprotection and Neurorecovery in Neurodegenerative Disorders. Int J Nanomater Nanotechnol Nanomed 2(1): 013-014. DOI: 10.17352/2455-3492.000008
© 2016 Sharma HS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Central nervous system (CNS) is vulnerable to various kinds of physical, chemical, metabolic or age-related insults leading to neurodegeneration. Neurodegenerative diseases either caused by aging or following trauma to the CNS results in misery for large number of people across the Globe involving high social costs for them to maintain a good life [1]. Thus, there is an urgent need to find novel solutions to reduce the burden of neurodegenerative disease induced problems in our aging populations. In this context, Alzheimer’s disease (AD) is causing huge social burden for the victims as no such therapy available for them to improve their lifetime disabilities [2,3]. This is especially critical to Military personnel who are the victims of brain or spinal cord injuries during combat operations [4]. There are reasons to believe that primary CNS injury could accelerate development of AD or Parkinson’s Diseases (PD) over time apart from post-traumatic stress disorders (PTSD) [5]. More often our young victims could also be critical following traumatic injuries to their CNS either following motor vehicle accidents or during combat operations in the battlefield [4]. All these young and old populations require a healthy life.

So far no suitable therapeutic strategies are successful in combating neurodegeneration in such diseases. Thus, exploration of novel therapeutic stargazes, drug delivery or even combination of several therapeutic agents are needed to find new clinical approach.

With recent advancement in nanotechnology, nanodelivery of drugs could be one of the new approached to treat such neurodegenerative diseases in future [5-8]. In our laboratory we have shown that cerebrolysin, a multimodal drug comprising a balanced composition of several neurotrophic factors and active peptide fragments when given using TiO2 nanowired technology is able to induce marked neuroprotection in CNS injuries as compared to the parent drug alone [5-10]. This suggests that nanodelivery of drugs may have far more superior neuroprotective effects in CNS injuries.

Apart from drug delivery to the CNS, recent studies show that stem cells could also be one of the most potent agents in inducing neuroprotection in a variety of CNS diseases including traumatic injuries [2-5]. Thus, there are evidences that stem cells transplantation enhances sensory motor and cognitive functions in stroke, CNS trauma and some neurodegenerative diseases e.g., Parkinson’s disease, Huntington’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis and spinal muscular atrophy [2-4]. Accordingly, stem cell delivery or transplant was used since last decades to induce neuroregeneration in the CNS following various types of insults [2]. However, stem cell transplantation is not always a success for improving the quality of the lives of the victims. There are many problems of stem cell transplantations that may include repeated administration, changes in immune function and survival of stem cells when administered in vivo for long time to maintain [2,6]. Thus, there is an urgent need to enhance the procedures of stem cell therapy to make them more effective for the benefit of the patients.

Some possibilities could easily be adapted to improve stem cell therapy for the neurological patients in future. These could be either use stem cell therapy employing nanotechnology or supplement stem cell delivery with known neuroprotective drugs to enhance the therapeutic benefits to patients.

Recent research from our laboratory as well as from other workers showed the potential benefit of stem cell therapy are enhanced when they are delivered using nanotechnology. In our laboratory we used TiO2 nanowired delivery of stem cell to enhance the viability of the neurons following CNS trauma or heat stroke [5]. Also we employed TiO2 nanowired Cerebrolsyin with stem cell therapy to enhance the neuroprotective efficacy of this combination in several animal models of CNS trauma, PD and AD [5-10]. These preliminary observations clearly support the idea that in future therapy we may look new avenues to combine stem cells with nanotechnology in addition with key neuroprotective drugs e.g., cerebrolysin for the benefits of patients.

This is certainly a matter of future policy issues where healthcare representatives or lawmakers may formulate new laws to have better therapeutic advances in neurological disorders for the benefit of patients when using stem cell therapies.

We are happy that the new International Journal of Nanomaterials, Nanotechnology and Nanomedicine is devoted on all aspects of nanotechnology at the cutting edge of science to provide a novel synthesis of various aspects on nanoparticles research in this developing field. We are sure that the journal will soon become an important reference point for the researchers, students, healthcare professional, healthcare providers and policy makers for the benefit of mankind in near future.

  1. The Lancet Neurology (2013) Joining forces to fight neurodegenerative diseases. Lancet Neurol 12: 119.
  2. Laroni A, Rosbo NK, Uccelli A (2015) Mesenchymal stem cells for the treatment of neurological diseases: Immunoregulation beyond neuroprotection. Immunol Lett 168: 183-190.
  3. Hunsberger JG, Rao M, Kurtzberg J, Bulte JW, Atala A, et al. (2015) Accelerating stem cell trials for Alzheimer's disease. Lancet Neurol S1474-4422.
  4. Zhuo J, Keledjian K, Xu S, Pampori A, Gerzanich V, et al. (2015) Changes in Diffusion Kurtosis Imaging and Magnetic Resonance Spectroscopy in a Direct Cranial Blast Traumatic Brain Injury (dc-bTBI) Model. PLoS One 10: e0136151.
  5. Sharma HS, Feng L, Lafuente JV, Muresanu DF, Tian ZR, et al. (2015) TiO2-Nanowired Delivery of Mesenchymal Stem Cells Thwarts Diabetes- Induced Exacerbation of Brain Pathology in Heat Stroke: An Experimental Study in the Rat Using Morphological and Biochemical Approaches. CNS Neurol Disord Drug Targets 14: 386-399 .
  6. Chen L, Huang H, Sharma HS, Zuo H, Sanberg PR (2013) Cell transplantation as a pain therapy targets both analgesia and neural repair. Cell Transplant 22: S11-19.
  7. Ruozi B, Belletti D, Forni F, Sharma A, Muresanu D, et al. (2014) Poly (D,L-lactide-co-glycolide) nanoparticles loaded with cerebrolysin display neuroprotective activity in a rat model of concussive head injury. CNS Neurol Disord Drug Targets 13: 1475-1482 .
  8. Sharma HS, Sharma A, Mössler H, Muresanu DF (2012) Neuroprotective effects of cerebrolysin, a combination of different active fragments of neurotrophic factors and peptides on the whole body hyperthermia-induced neurotoxicity: modulatory roles of co-morbidity factors and nanoparticle intoxication. Int Rev Neurobiol 102: 249-276 .
  9. Sharma A, Muresanu DF, Mössler H, Sharma HS (2012) Superior neuroprotective effects of cerebrolysin in nanoparticle-induced exacerbation of hyperthermia-induced brain pathology. CNS Neurol Disord Drug Targets 11: 7-25.
  10. Sharma HS, Muresanu DF, Lafuente JV, Tian ZR, Ozkizilcik A, et al. (2015) Nanodelivery of Mesenchymal Stem Cells with Cerebrolysin potentiates neprilysin level and decreases brain pathology and amyloid-beta peptide in Alzheimer’s Disease. Soc Neuroscience abstr 689.15/K8, 45th annual meeting , Chicago, IL, USA, October 17-21.

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