1. Methodology in QSAR

      Govind Sharma, Yogesh Vaishnav*, Surbhi Tiwari

      Quantitative structure-activity relationships (QSARs) are mathematical models that attempt to relate the structure derived feature of a compound to its biological or physicochemical activity. QSAR works on assumption that structurally similar compounds have similar activities. Therefore these models have predictive and diagnostic abilities. They can be used to predict the biological activity (e.g., IC 50) or class(e.g., inhibitor versus non inhibitors) of compounds before the actual biological testing. Quantitative structure-activity relationships (QSARs) attempt to correlate chemical structure with activity using statistical approaches.

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    2. Formulation and Characterization of Clobetasol Propionate Niosome

      Shashikant Chandrakar*, Amit Roy

      The aim of this investigation was to prepare, and characterize Clobeatsol propionate niosomes using different ratio of cholesterol and nonionic surfactant by modified hand shaking, lipid film hydration technique. Formulations were characterized with respect to surface morphology, particle size, entrapment efficiency, zeta potential and drug permeation study. The above prepared optimized noisome were incorporated into carbopol-934 gel and compared for permeability study. Vesicle size was found in nanometer ranges which are optimum for delivery of drug through the skin.

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    3. Scope & Importance of Virginal Delivery System

      Amit Roy, Ananta Choudhury*, Sanjib Bahadur, Suman Saha

      The purpose of study is to highlight the scope and importance of vaginal drug delivery system. Several studies proven that vagina is an effective route for drug administration intended for local action as well as systemic action. This route offers many advantages due to its large permeation area, permeability to large molecular weight drugs, rich vascularization, avoidance of first pass metabolism and relatively low enzymatic activity. Through this route steroidal compounds, spermicidal agents are already delivered to obtain suitable therapeutics action for prolong period of time with minimal side effects.

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    4. Pro-stimulatory Potentials of Methemoglobin in Inflammation during Cerebral Malaria through Heme Polymer Formation

      Avinash Sahu, Satyendra Kumar Yadav, Vijay Bahudar Singh, Baby Binnu Sahu, Rohitas Deshmukh*

      Cerebral malaria (CM), a severe form of malaria causes life threatening complication. Methemoglobin (MetHb), released from infected RBC causes inflammation due to its ability to produce free radicals. MetHb can catalyze heme to heme polymer formation in the presence of hydrogen peroxide utilizing its peroxidase activity (R2=0.9722). More-Over, peroxidase inhibitors and the substrate inhibits heme polymer formation further confirm the role of peroxidase activity in polymerization process. Methemoglobin process both substrates (H2O2 and hemin) specifically with a Km value of 6mM and 9.33 µM respectively to form heme polymer. The heme polymer has chemical and structural properties similarities with known synthetic heme polymer (β-hematin).

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    5. Nanotoxicity: An Unmet Challenge

      Neha Kurkure, Anupriya, Gunjan Jeswani*

      Any substitute ranging from 1- 100 nm, known as nanomaterials, constitutes the bearer of most advancing technology, nanotechnology. The toxicity from nanomaterials is due to their exceptional properties which are attributable to their small size, chemical composition, small size, surface structure, aggregation, solubility and shape. Over the past number of years several studies have indicated that nanomaterials produce ultimate impact on health and the environment. An important mechanism of nanotoxicity is the generation of reactive oxygen species (ROS). There are four main human routes of exposure namely: dermal, inhalation, ingestion and injection. Environmental routes of exposure are manifold. Most important examples are wastewater system and disposal of nanomaterials or products of research laboratories, manufacturing companies and household.

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    6. Medicinal Plants used as Anticancer Drug

      Malti Sao*

      India is the largest producer of medicinal plants and is precisely called the “Botanical garden of the world”. Herbal medicine are the widely used for various diseases as the content various types of antioxidant and related active constituent which help in building the healthy cells which help for healthy person. There are many diseases found in the world, cancer is also one of them which largely effect human beings. Plants an important role in cancer prevention, as well as in therapy. In the proliferation stage the cancerious cells are in maturation stage so that if we used herbal medicines like vinca, neem, turmeric, tulsi, ginger etc.

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    7. Polymer Grafting: Novel Approach in Drug Delivery

      Monika Bhairam*, Amit Roy, Sanjib Bahadur Pragya Baghel

      The modification of polymers has received much attention recently. Among the methods of modification of polymers, grafting is one of the promising methods. In principle, graft co polymerization is an attractive method to impart a variety of functional groups to a polymer. Graft co-polymerization initiated by chemical treatment, photo-irradiation, high-energy radiation technique, etc. In the past several years, there has been increased emphasis on applications of grafted polymers. The modified polymers through grafting have a bright future and their development is practically boundless.

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    8. Synthesis and Biological Activity of some Thiazole Compounds Containing and Azetidinones and Thiazolidinones Derivatives

      Ravitas Deshmukh*, Arvind Kumar Jha, Alok Singh Thakur, P. Sudhir Kumar

      Thiazole, azetidinone and Thiazolidinones are some heterocyclic ring which posses many biological activities one of them are anti-inflammatory and analgesic activity and the drug which are available are less potent or dose required are very high. In these study attempt is made to remove both of these problems. Various 3-chloro-4 (4-substitutedphenyl) -4-methyl-1-(4-(2 (naphthalene-1-yl) hydrazinyl) thiazole-2-yl)1,3thiazolidin-4-one have been prepared by treating Napthalen-1amine with hydrazine in alkaline condition to get 1- (Naphtalen-1yl) Hydrazine, methanolic solution of these was treated with chloro acetyl chloride to get 2-Chloro-N’-(Naphthalen-1- yl)Acetohydrazide, the methanolic solution of these was refluxed with thiourea for 2-3 hrs to get 5-(2-(Naphthalen-1-yl)Hydrazinyl)

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    9. Formulation of Sustained Release Tablets of Glipizide using Hibiscus Rosa Sinensis Mucilage

      Sanjib Bahadur, Pragya Baghel*, Amit Roy

      Glipizide is an oral hypoglycemic drug prescribed for type II diabetic patients. This work aims to use Hibiscus rosa-sinensis leaf mucilage mucilage for formulation of sustained release glipizide tablets. Mucilage was extracted from Hibiscus rosa-sinensis leaves using acetone. The extracted mucilage was dried and triturated to fine powder. Glipizide tablet were prepared by wet granulation using extracted mucilage in different proportion. The formulated tablets were subjected to various evaluations like weight variation, hardness, thickness, friability, appearance and in vitro drug release. Drug excipient compatibility study was conducted using FTIR.

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    10. Dual Drug Loaded Liposomes

      Saha S*, Roy A, Bahadur S, Choudhury A

      Curcumin is a functional food, which provides a wide range of health benefits including anti-cancer activity and considered as a suitable alternative for chemotherapeutic agents. The major barriers to the clinical usefulness of curcumin in the treatment of cancer is poor oral bioavailability. However, poor oral bioavailability of curcumin is mainly due to its poor aqueous solubility, intestinal metabolism, hepatic metabolism and rapid systemic clearance. These limitations can be overcome by formulating dual drug loaded liposomal formulation.

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