1. Eudragit Based Nanoparticulate Drug Delivery System for Treatment of Glaucoma

      Parmanand Verma*, Arunima Kaushik Verma

      Glaucoma is an ocular disorder characterized by increased intra ocular pressure. Acetazolamide is used for its treatment. But its oral administration results in low bioavailability. This is due to its low solubility and low permeability profile. In present study this drug is loaded in Eudragit Nanoparticles by nanoprecipitation method. The in vivo studies in rabbits showed that the ocular hypotensive activity was higher as compared to topical acetazolamide solution.

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    2. Breaking the Barrier of Hepatic Metabolism by the Application of a Novel Concept of Buccal Patches

      Lilima Baghel, Pragati*

      Buccal drug delivery systems are design to deliver drugs systemically or locally via buccal mucosa. In which the drugs release can occur when a dosage form is placed in the outer vestibule between mucosa and gingival. among the various route of drug delivery, oral route is perhaps the most preferred to the patient and the clinical alike. Some advantages of peroral administration are hepatic first pass metabolism and enzymatic degradation within GIT. Buccal drug absorption occurs by passive diffusion of the nonionized species. There are two type of buccal dosage form, they are matrix type and reservoir type. The component which are mainly used in the formulation of buccal dosage form that are drug substance, bio adhesive polymer, backing membrane permeation enhancer.

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    3. Development and Optimization of Nanostructured Lipid Carrier-Enriched Cream for Topical Delivery of Betamethasone Valerate

      Prameet Singh and Preeti K. Suresh*

      Nanostructured lipid carriers (NLC) for topical delivery of betamethasone valerate (BMV) were designed by solvent diffusion technique using response surface methodology (with 3 level factorial design and quadratic model).In the present study, the selected independent variables were the lipid composition (ratio of glycerylmonostearate:oleic acid) and surfactant concentrationas formulation variable and sonication time as a process variable. The dependent variables were the drug entrapment efficiency and drug loading within NLCs. The physicochemical attributes of NLCs were assessed using transmission electron microscopy, scanning electron microscopy and differential scanning calorimetry.

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    4. Resealed Erytherocyte as a Novel Drug Delivery System for Cancer Therapy

      Deepika, Preeti Thakur*, Ajazuddin, Amit Alexander, D. K. Tripathi

      Drug delivery is now entering quite an exciting and challenging era. Significant high costs involved in the development of new drug molecule has compelled scientists all over the world to search for alternative ways of administering the existing drug molecules with enhanced effectiveness. Improper drug administration inside the biological system not only causes distress to other body tissues but also demands more therapeutic molecules to elicit the appropriate response. Among the various carriers used for targeting drugs to various body tissues, the cellular carriers meet several criteria desirable in clinical applications, among the most important being biocompatibility of carrier and its degradation products.

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    5. Formulation & Characterisation of Microemulsion with Nonionic Surfactants

      Supriya Biswas*, Richa Sharma

      Pseudoternary phase diagram was investigated which reveals the influence of hydrophobic chain lengths of surfactant, cosurfactant, oil & their(S/Co) different ratios on the phase behaviour of surfactant/ cosurfactant/ oil/ H2O. The total area of microemlsion (ME) regions were determined 2:1(w/w) ratio of S/Co was found to show largest ME region. Formulation of MEs increased with an increase of hydrophobic chain length of non ionic surfactant, which was antagonistic to the trend for oil. Among the alcohol co surfactant chosen, n-butanol formed largest ME region. Various physical parameters give idea about ME region formed.

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    6. Various Approaches for the Formulation of Nanocapsules

      Ruchi Singh*, Nidhi Singh, Ajazuddin, Amit Alexander, D. K. Tripathi

      A review of the state of knowledge on nanocapsules prepared from preformed polymers as actives Substances carriers is presented. Other advantages of nanoencapsulated systems as active substance carriers include high drug encapsulation efficiency due to optimized drug solubility in the core, low polymer content compared to other nanoparticulated systems such as nanospheres, drug polymeric shell protection . This entails a general review of the different preparation methods:nanoprecipitation, emulsion–diffusion, double emulsification, emulsion-coacervation, polymer-coating and layer-by-layer, from the point of view of the methodological and mechanistic aspects involved, encapsulation of the active substance and the raw materials used.

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    7. Polymeric Lipid Hybrid Nanopanoparticles (PLN): Versatile Carrier System for Antigen

      Minz Sunita

      Polymer Lipid Hybrid Nanoparticles (PLN) having the liposomes as well as polymeric nanoparticles features. Polymeric core (hydrophobic) and a polymeric shell (hydrophilic) separated by a single layer of lipid. In addition to potential applications in drug delivery and PLN can also be used as novel adjuvants in the field of vaccination. Biodegradable poly (lactic-co-glycolic acid) and phosphatidylcholine are used as the polymer and lipid models, respectively. PLN has been formulated by the DESE (Double Emulsion Solvent Evaporation) method. Antigen Bovine Serum Albumin (BSA) which is aqueous solubility has been used. The three-factored factorial design with three levels was used in this study.

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    8. Formulation Development and Characterization of Chitosan Multipaticulate System for Treatment of Colorectal Cancer

      Sandeep Kumar Sonkar* and S. K. Lanjhiyana

      In the present work, chitosan microspheres with a mean diameter between 42.32µm and 49.44µm, were produced by ionically cross linking method of chitosan, and tested for treatment of colorectal cancer. Aiming at developing a suitable colon specific strategy, Fluorouracil (Fu) was encapsulated in the microspheres, following Eudragit S-100 coating by solvent evaporation technique, exploiting the advantages of microbiological properties of chitosan and pH dependent solubility of Eudragit S-100.Different microsphere formulations were prepared varying the ratio FU:chitosan (1:2 to 1:10), stirring speed (1000–2000 rpm), and the concentration of emulsifier Sodium lauryl sulfate (0.5–1.5% (w/v)).

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    9. QSAR and Pharmacophore Studies on Arylbenzofuran Derivatives as Histamine H3 Receptor Antagonists

      Priyanka Sinha, Piyush Ghode, Sanmati K. Jain*

      Quantitative structure activity relationship (QSAR) studies using Molecular Design Suite (VLife MDS) software and pharmacophore studies using a web based pharmacophore identification server Pharmagist were performed on 29 compounds belonging to arylbenzofuran chemical class for their histamine H3 receptor antagonistic activity. 2D QSAR analysis was performed using partial least square regression (PLSR) while k-nearest neighbour molecular field analysis (kNN-MFA) methodology was applied to derive 3D QSAR models. The variable selection method applied for both strategies was stepwise forward backward. The best 2D QSAR model had squared correlation coefficient (r2) = 0.8662, cross validated correlation coefficient (q2) = 0.6029 and predictive correlation coefficient (pred_r2) = 0.3940.

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    10. QSAR and Pharmacophore Studies on Thiazolidinone Derivatives as Potential Epidermal Growth Factor Receptor Inhibitors

      Piyush Ghode*, Ravi Tripathi, Sanmati K. Jain

      The epidermal growth factor receptor (EGFR) inhibitory activity of some thiazolidinone analogues was subjected to 2D and 3D quantitative structure activity relationship analysis and pharmacophore studies using Molecular Design Suite (VLife MDS) software and web server Pharmagist respectively. 2D QSAR analysis was performed using partial least squares regression (PLSR) while 3D QSAR models were generated using k-nearest neighbour (kNN) methodology. The variable selection method applied for both strategies was stepwise forward backward. The QSAR models generated by both the methods were subjected to internal and external validation. The best 2D QSAR model had r2, q2 and pred_r2 values of 0.8758, 0.8002 and 0.9141 respectively.

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