1. Novel Drug Delivery Systems for Herbal Phytoconstituents

      Arunima Kaushik Verma*, Parmanand Verma

      Drugs of plant origin are widely being used all over the world these days and have been recognized by researchers for their better therapeutic value as they are having very low adverse effects as compared with allopathic medicines. These natural drugs of plant origin may be better utilized by delivering it by a suitable delivery system. Novel drug delivery systems are now a days getting huge popularity. Present study is focused on various Novel drug delivery systems for the delivery of various herbal medicines.

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    2. Nanocosmaceuticals: A New ERA in Cosmetics

      Silviya Naina Singh*, Barira Khan, Varnika Sahu, Gunjan Jeswani

      Nanotechnology is the engineering of functional systems at the molecular scale, deals with particles sizes between 1 and 100 nanometre. Nanoparticles and other nanostructure materials have unique properties which cannot be achieved when working with the bulk form of the material. As today’s consumers are much concerned about appearance, the use of nanotechnology in cosmetics has increased significantly. The applications of nanotechnology and nanomaterials can be found in many cosmetic products including moisturisers, hair care products, make up and sunscreen. The two main uses for nanoparticles in cosmetic products are UV filtering and delivery of active ingredients. Titanium dioxide and zinc oxide are both used extensively in sunscreens to prevent UV damage to the skin.

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    3. PLGA Based Novel Drug Delivery System for Treatment of Cancer

      Parmanand Verma, Govind Sharma, Kalyani Dewangan*

      Cancer is disorder of uncontrolled growth of cell. Nanotechnology is getting huge popularity day by day. Because of numerous advantages associated with this delivery system it is very popular among researchers. Various drugs for the treatment of cancer are also being loaded in nano carriers. Various polymers are used for the preparation of nanoparticles. PLGA is one of those. In present study PLGA based drug delivery systems are covered.

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    4. Pharmaceutical Significance and Biomedical Application of Cellulose

      Mithleshwari Thakur, Hemant Badatiya*, Ajazuddin, Amit Alexander, D. K. Tripathi

      The amalgamation of polymer and pharmaceutical sciences led to the introduction of polymer in the design and development of drug delivery systems. Polymeric delivery systems are mainly intended to achieve controlled or sustained drug delivery. Polysaccharides fabricated into hydrophilic matrices remain popular biomaterials for controlled-release dosage forms and the most abundant naturally occurring biopolymer is cellulose; so hdroxypropylmethyl cellulose, hydroxypropylcellulose, microcrystalline cellulose and hydroxyethyl cellulose can be used for production of time controlled delivery systems. Additionally microcrystalline cellulose, sodium carboxymethyl cellulose, hydroxypropylmethyl cellulose, hydroxyethyl cellulose as well as hydroxypropyl cellulose are used to coat tablets.

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    5. Evaluation of Antibacterial Effect of Ethanol Extract of Clerodendrum Indicum Against E. coli and Staphylococcus Aureus

      Chandrol Sweta*, Ojha Priya, Dwivedi Shubhangi, Sahu Lokesh, Panda D.P.

      In the present study ethanolic extract of aerial part of Clerodendrum indicum (Verbenaceae) was explored for possible antibacterial activity against bacteria that attacks on wound e.g. E.coli (Gram negative) and Staphylococcus aureus (gram positive). Ethanolic extract of varying concentration 0.5, 1.0, 1.5, & 2% was prepared and tested against test organism using well diffusion method. Among all these extracts of Clerodendrum indicum, 2% showed optimum activity which was analysed by comparing with standard (Gentamicin). Moreover it was also found that the ethanolic extract of Clerodendrum indicum was equally efficacious as the choosen standard one.

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    6. Efficacy of Polymeric Nanoparticles in Management of Neurodegenerative Disorders via Encapsulation with PLGA Particles

      Shubhangi Dwivedi*, Peeyush Kumar, D.P. Panda

      Nanoparticles could potentially transfigure management for neurodegenerative diseases which implies the application of neurotrophic factors to amend neuronal survival and synaptic connectivity and thus promising therapeutic approach for many diseases, however, due to limitations posed by the restrictive blood brain barrier (BBB), it is very difficult to ensure long-term administration in the brain. Here in this study L-DOPA-loaded PLGA- NPs were fabricated by an emulsification/solvent diffusion method. The 6-OHDA-induced rat model (400 mg/kg) was utilized to investigate the efficacy of nano-DOPA in a set of behavioral tests like placing task, footfault asymmetry test etc.

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    7. Nanotechnology in Pharmaceutical Product Development

      V. Kedarnath, Shekhar Verma*

      A number of new molecular entities (NMEs) selected for full-scale development based on their safety and pharmacological data suffer from undesirable physicochemical and biopharmaceutical properties, which lead to poor pharmacokinetics and distribution after in vivo administration. An optimization of the preformulation studies to develop a dosage form with proper drug delivery system to achieve desirable pharmacokinetic and toxicological properties can aid in the accelerated development of these NMEs into therapies. Nanoparticulate drug delivery systems show a promising approach to obtain desirable druglike properties by altering the biopharmaceutics and pharmacokinetics properties of the molecule.

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    8. Evolving Concept of Nano Drug Delivery System

      Kusum Lata Yadav*, Mukta Lilhare, Omkar Prasad Rathore, Mohit Sahu, Harish Sharma

      Nanotechnology is the art of characterizing, manipulating and organizing matter systemically, at the nanometer scale, which has created a revolution in science, engineering, technology, drug delivery and therapeutics. Nano-sized systems could be designed into a more sophisticated system associated with its physical dimension of less than 100 nm. Nanotechnology, as a novel technology, offers opportunities for the production of new generation of sophisticated drug delivery systems. There are now a wide range of nano-systems, not only nanoparticles and nanocapsules but lipid complexes, polymeric micelles. Herein, we discuss two important aspects of nanomedicine—drug delivery and tissue engineering. Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physico-chemical factors to improve or replace biological functions. Tissue engineering cover a broad range of applications, in practice the term is closely associated with applications that repair or replace portions of or whole tissues (i.e., bone, cartilage, blood vessels, bladder, skin, muscle etc.). Often, the tissues involved require certain mechanical and structural properties for proper functioning. Nanotechnology and tissue engineering are used for better designs to improve biochemical properties.

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    9. Development and Evaluation of Solid Fat Nanoemulsions of Anti-Tuberculosis Drug

      Manoj Kumar, Pandey R.S., Dangi J.S.

      Formulations were prepared by modified lipid hydration method and evaluate the potential of solid fat nanoemulsion SFN for selective delivery of an anti-tuberculosis drug, rifabutin, to pulmonary tissues particularly alveolar macrophages as this is the densest site of tuberculosis infection. The formulations were characterized for zeta potential, polydispersity index, particle size, percent drug entrapment and in vitro drug release. Pharmacokinetics and biodistribution of formulations and plain drug upon nebulization of nanoparticles or intravenous administration to Balb/c mice were also investigated. The toxicity and targeting potential of the prepared formulation were assessed with alveolar macrophage viability, haematological, hepatotoxicity and lung histopathology studies.

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    10. Newer Pharmacophric Approach: 6-Substituted-6H-Pyrrolo [3,4-D]Pyridazine Derivatives for Gaba Mediated Anticonvulsant Activity

      P. Sudhir Kumar*, Alok Singh Thakur, Ravitas Deshmukh

      A newer series of 6-aryl-6H-pyrrolo [3,4-d]pyridazine pharmacophores has been synthesize for anticonvulsant activity. There are numerous changes are performed at the six position in the pyrrolopyridazine ring to evaluate the anticonvulsant potency. This position of the ring provides a great scope for SAR study to improve the activity. Some simple aryl substituted compounds like 4a, 4b, 4f, 4i and 4k have shown a remarkable activity, but the 4-methoxyphenyl containing compound (4k) has found to be most active. The formation of benzylidene (schiff base) of 6-aryl ring as in 6b and 6d were also carried considerable anticonvulsant activity but lesser than the initial lead.

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