1. Nanooncolgy: A Radical Approach for the Treatment of Ovarian and Metastatic Breast Cancer

      Mandeep Singh Kapoor*, Sanjay Kumar Gupta, Surendra H. Bodakhe

      Breast cancer is one of the most common cancers in women in the developed countries of the world and it is the cause of death in approximately 20% of all females who die from cancer in these countries. Although relatively little is known about the molecular mechanisms leading to breast cancer development, breast cancers have probably been studied more than any other tumor type with regard to oncogene expression. MYC, ERBB2 or one of the RAS families has been found to be expressed in over 60% of cases. Clinical and experimental data have indicated that exposure to estrogens is one of the leading causes of sporadic female breast cancer and in December 2002 estrogen was declared to be a known human carcinogen by the National Toxicology Program of the National Cancer Institute in the USA.

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    2. Transutaneous Immunization with Hepatitis B Surface Antigen (HBSAG) Nanoparticle Adjuvanted with Aluminium Phosphate for Treatment of Hepatitis B

      Monika Kaurav*, Sukant Kumar Sahoo and R.S.Pandey

      Transcutaneous immunization one of the most promising and well known immunization method now-a-days. Vaccine administration through the skin painlessly via a larger surface area than that used by a needle, referred to as transcutaneous immunization (TCI). The Nanoparticles are sub-nanosized colloidal structure composed of synthetic or semi synthetic polymers and having size range between 1-1000 nm. Hepatitis is an inflammation of liver, most commonly caused by a viral infection. Mainly five types Hepatitis are A, B, C, D and E. In particulars type B leads to chronic disease in hundreds of thousands people. In present study, we prepared nanoparticles by using aluminium phosphate and HBsAg.

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    3. Mutation in Active Site: Majaor Problem for Designing New Inhibitors for Swine Flu

      Mukesh Kumar Gupta*, Jawahar Singh Dangi

      Swine flu is a contagious and acute respiratory which cause morbidity and mortality worldwide. This is due to classical influenza virus H1N1 strains which have known for its ability to mutate.Currently there are two classes of antivirals medicine for swine flu, amantadine and neuraminidase inhibitors. Due to highly mutation till now there is no any appropriate drug and vaccine also.The swine flu virus, however, typically affects the younger population, i.e. from 5 to 65 years. Present study deals the drug against mutant protein in H1N1 flu. We can target thee surface protein Neuraminidase (NA), Hemagglutinin (HA) and M2-protein channel which present on virus cell and are responsible for the penetration in host cells.Among this Neuraminidase (NA) is good target for inhibitor.

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    4. Development of Qquality Control Parameter of A Unani Formulation "Saffof Bars"

      Mukesh Sharma*, Ajazuddin, Amit Alexander

      The Unani System of Medicine pioneered in Greece and was developed by Arabs into an elaborate medical science based on the frame work of the teaching of Buqrat (Hippocrates) and Jalinoos (Galen). This system is based on Hippocatic theory of four humours viz. blood, phlegm, yellow bile and black bile, and the four qualities of states of living human body like hot, cold, moist and dry. Saffof Bars is a blood purifier.Saffofbars made of a mixture of herbs and edible salts, including Geru(Red ochre).Saffof Bars help against bacterial and fungal infections in humans and used for Therapeutic relief from Vitiligo/Leucoderma, Pruritis/Itching.Saffof Bars (SBL)was prepar...

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    5. AB-Intitio Study of OLED Electrodes for the Fundamental Application and Properties by Using Density Functional Theory Approach

      O.P.Verma*, M.R. Meshram, A.K. Mishra, Mohan L. Verma

      Organic Light Emitting Devices (OLEDs) have long used indium tin oxide (ITO) as a highly-transparent, conducting anode for the case of polymer light-emitting devices, a metal cathode with a low work function has also been necessary for the attainment of facile electron injection and efficient device operation. Due to the fact that the power efficiency of OLEDs can exceed that of incandescent lamps, discharge lamps, lighting purposes is very promising with organic layers prepared in vacuum from low molecular weight organic semiconducting materials. In contrast to that, the established liquid crystal displays only changes the polarization state of the illuminating light, an effect which is strongly viewing angle dependent and the lowering of the operating voltages of OLEDs.

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    6. Nanocarriers Role in Reversing Multi Drug Resistance

      Pawan Tekchandani* and Shivani Rai Paliwal

      A major hurdle to chemotherapy is development of multi drug resistance due to microenvironmental selection pressures. In this review we discuss the application of nanotechnology-based delivery systems to overcome MDR in solid tumors. Evidence from the literature illustrates the development of various types of engineered nanocarriers specifically designed to enhance tumor-targeted delivery through passive and active targeting. Moreover, multi-functional nanocarriers are developed to enhance drug delivery and overcome MDR by combination therapy with MDR modulators (e.g., with P-glycoprotein substrates), agents that regulate intracellular pH, agents that lower the apoptotic threshold (e.g., with ceramide).

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    7. Nanotechnological Products: Evaluation Facilities in India

      Parmanand Verma, Nelam Kumar*, Naveen Kumar Chandrakar, Sourabh Tamrakar

      Nanoproducts are getting huge popularity among present researchers. Diverse range of drugs is being loaded in various Nanotechnological carriers. Some of those are already in market and some are under pipe line. Major obstacle in the way of nanotech research is the characterization of final formulations prepared. The equipments used for characterization of these products are very costly and are generally not available in all institutions of our country. There are some institutions in India which do have the facilities and they also offer the same for external users too. In present review we attempted to enlist those institutions which provide the facilities for characterization of Nanoproducts.

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    8. Omparative In-vitro Cytotoxic Evaluation and Antioxidant Potential of Naringin and Qurcetin-3-O-Rhamnoside

      Abhishek Kumar*, S.P. Pattanayak, S. Jha, Dhananjay Kumar

      In-vitro cytotoxic and cell viability assays of two pharmacologically active polyphenolic compounds were performed on breast cancer cell lines. Further, antioxidant potential of these molecules was studied on oxidative damage of DNA in-vitro. Two naturally occurring flavonoids naringin (NA) and Quercetin3-O-rhamnoside (Qr) were evaluated for their cytotoxic activity against MCF-7 cell lines using SRB assay protocols at various concentrations of 25, 50, 100 and 200 µg. Also, MTT and trypan blue cell viability assays were done on these concentrations. Oxidative defence of DNA cleavage (H2O2 and UV) was checked using pBR322 DNA at concentrations of 25, 50 and 100µg.

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    9. Advancement in Novel Drug Delivery System: Self-Emulsifying Drug Delivery Systems

      Anandsoni, Anjali Minocha, Amit Alexander, Ajazuddin, D. K. Tripathi

      Self-emulsifying formulationsare isotropic mixtures of drugs, lipids (natural or synthetic oils) and emulsifiers (solid or liquid), usually with one or more of hydrophilic cosolvents / co-emulsifiers. The size and charge of oil –droplet in the emulsion formed other important factors that effects gastrointestinal absortion efficiency. According to biopharmaceutical classification (BCS) the 40% of active substances are poorly water soluble, high intra and inter subject variability. To overcome this problem, various technologies are developed like solid dipersion or cyclodextin complex formulation. More attention has been given to lipid –based formulation with particular emphasis on self -emulsifying drug delivery system to improve the oral bioavailability of lipophilic drugs.

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    10. The Diagnosis and Management of Severe Life-Threatening Hyperthyroidism During Pregnancy

      Keshaw Garhewal, Deepak Kumar Sahu, Ajazuddin, Amit Alexander, D. K. Tripathi

      Changes in thyroid hormone concentrations that are characteristic of hyperthyroidism must be distinguished from physiological changes in thyroid hormone economy that occur in pregnancy, especially in the first trimester. Approximately one to two cases of gestational hyperthyroidism occur per 1000 pregnancies. Identification of hyperthyroidism in a pregnant woman is important because adverse outcomes can occur in both the mother and the offspring. Graves disease, which is autoimmune in nature, is the usual cause; but hyperthyroidism in pregnancy can be caused by any type of hyperthyroidism--eg, toxic multinodulargoitre or solitary autonomously functioning nodule.

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