1. Optimization of Lipid Concentration for the Development of Anticancer Agent Based Ethosomal Formulation

      Rakesh Raj*, Pooja Mongia Raj and Alpana Ram

      Cancer is the major drastic disease in present scenario. Skin cancer generally treated by conventional cream that leads skin irritation and low therapeutic effect. Development of vesicular carrier for the enhancement of tandermal flux is the major concern towards non invasive approach. In this study we developed lipid based elastic carrier using soya phosphatidyl choline, ethanol and 5-fluoro uracil as model drug. Developed carrier was characterized for vesicle size, size distribution and zeta potential. Transmission electron microscopy was used to estimate surface morphology. Entrapment efficiency of the prepared carrier was evaluated by sephadex G50 column method. Results showed spherical, unilamellar structures with low polydispersity, nanometric size and improved entrapment efficiency over other delivery formulations. Keywords: Ethosome, 5-Fluoro uracil, Transdermal delivery, In vitro release

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    2. Lecithin/Chitosan Nanoparticles for Transcutaneous Immunization

      Raziya K. Farooqui and Ravi Shankar Pandey*

      Transcutaneous immunization is an attractive mode of immunization due to improved safety, ease of use over needles, availability of large application areas and better patient compliance due to painless administration. In present study, Chitosan/lecithin nanoparticles (LCNs) incorporating model antigen Ovalbumin (OVA) was prepared and evaluated for their immune stimulating efficacy following topical application. OVA loaded LCNs were prepared and characterized for size, shape, antigen loading efficiency, zeta potential and antigen integrity. In vitro permeation study was performed in rat skin using Franz diffusion cell. Skin penetration efficiency of LCNs was assessed by fluorescence microscopy.

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    3. Phytochemical Screening of Plant Apium Leptophyllum Seeds

      Shiba Morris*, Arvind Kumar Jha, Yashwant Swarnakar

      Phytochemicals are non-nutritive plant chemicals that have protective or disease preventive properties. They are nonessential nutrients, meaning that they are not required by the human body for sustaining life. It is well-known that plant produces these chemicals to protect themselves but recent research demonstrate that they can also protect humans against diseases. Apium leptophyllum is also traditionally known as a Carminative, Antibectarial, Antifungal, Anthelmintic, Anti inflammatory (used in rheumatic disorders, inflammation of the urinary tract), Diuretic, Carminative, Nervine, Sedative, Antiemetic, Antispasmodic, Antiseptic (used in bronchitis, asthma, as well as liver and spleen diseases), Emmenagogue, Tranquilizer and Anticonvulsant.

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    4. Regulation of Nanomaterials: Issues and Facts

      Gunjan Jeswani*

      While the applications of nanotechnogy are increasing by leaps and bounds their regulatory issues are gaining importances proportionately. Nanotechnology is concerned with the production of materials which have at least one dimension below 100 nm. Nevertheless, the definition of nanomaterials has been a matter of discussion since its inception. As the regulatory frame work of different countries is slightly different from each other various organizations and regulatory systems worldwide are attempting to harmonize the definition of nanomaterials.

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    5. First Principle Study on Interaction of ZnO Nanoribbon and Polyethylene Glycol

      Youman Kumar Sahu*, Mohan L Verma, Anjali Oudhia, B. Keshav Rao and Aarti Chaudhary

      A density functional theory based first principle study is performed to understand the mechanism of interaction of ZnO molecules with a capping agent PEG. It is divided into three steps; first step is the optimization of single PEG chain, ZnO nanoribbon (ZNR) and PEG chain with ZNR. The structural analysis is a second step, where noticeable structural change is observed in ZNR in presence of PEG chain. In final step, the electronic structure study is performed and corresponding DOS, PDOS and band-gap are compared. A computational program SIESTA is used under density functional environment.

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