N Amraoui1*, M Meziane1, A Lahlou1, S Gallouj1, S Rabhi2, W Bono2 and F Mernissi1
1Department of Dermatology Venereology, Hassan II University Hospital Fez
2Department of internal medicine, Hassan II University Hospital Fez
Received: 18 April, 2015; Accepted: 26 May, 2015; Published: 28 May, 2015
Amraoui Nissrine, Department of Dermatology Venereology, Hassan II, University Hospital Fez Marocco; Tel: 00212666132727; Email:
Amraoui N, Meziane M, Lahlou A , Gallouj S, Rabhi S, et al. (2015) Multiple Autoimmune Syndrome with Vitiligo, Autoimmune Thrombocytopenia and Autoimmune Dermoepidermal Bullous Dermatosis. Int J Dermatol Clin Res 1(1): 011-013. DOI: 10.17352/2455-8605.000005
© 2015 Amraoui N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Multiple auto-immune syndrome is defined by the coexistence of at least three different autoimmune diseases. Immune genetic predisposition and abnormalities of humeral and cell-mediated immunity seems to be implicated in their genesis.
In this observation, we describe a combination of three autoimmune diseases in the same patient namely vitiligo evolving since childhood, autoimmune dermo epidermal bullous dermatosis and autoimmune thrombocytopenia. The discovery of such associations may limit the therapeutic arsenal. And temporal sequence indicates that long-term surveillance of these patients is necessary to watch the occurrence of another autoimmune disease.
Multiple autoimmune syndrome is defined by the coexistence of at least three different autoimmune diseases which can occur simultaneously or over several years of evolution. We report an exceptional association of vitiligo, autoimmune thrombocytopenia and autoimmune dermoepidermal bullous dermatosis.
A young patient of 35 years presented since the age of 14 achromic non-painful or pruritic lesions which gradually extended to the level of the body. 4 years ago he developed intermittent oral and nasal erosions associated with red eyes and a decrease of visual acuity impeding his daily and professional activities. He also reported episodic appearance of some liquidiennes skin lesions without signs of infection or systemic disease.
Ocular examination revealed bilateral red eyes with Symblepharon, and corneal dystrophy (Figure 1). Cutaneous examination revealed at the left leg the presence of tense bullae with clear contents based on healthy skin, associated with hemorrhagic erosions (Figure 2). The Nikolsky's sign was negative. There were also extensive achromic patches (Figure 3).
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